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Targeting the biology of ageing with mTOR inhibitors to improve immune function in older adults: phase 2b and phase 3 randomised trials

El ATP (adenosintrifosfato) acta como cosustrato para ambas enzimas

In addition, decreased GLT-1 expression was shown in several TBI preclinical studies [147], which is consistent with the decreased EAAT2 activity observed in TBI patients [171]

Integrated platforms (e.g., brain organoids coupled with clinical cohorts) are needed to define therapeutic windows and contraindications

Ultimately, prevention remains the most effective strategy

While these drugs are effective, long-term use in aging individuals, whose metabolic function is usually compromised, can lead to drug dependency and resistance (19)