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They will also set an upper limit on the total weekly dose (for example, some experts recommend not exceeding approximately 300 mg per week in subcutaneous dosing without further evaluation) to minimize any risk of adverse effects

Content reflects FY2026 ICD-10-CM guidelines (effective October 1, 2025 September 30, 2026) and incorporates current clinical practice standards from the Crohns & Colitis Foundation and the American College of Gastroenterology (ACG)