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Son taux diminue avec lge (surtout partir de 45-50 ans) et lors de laugmentation des besoins de dfense de lorganisme (immunit, dtoxification hpatique, dfenses antioxydantes)

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Acknowledgements We extend our gratitude to the funding supports provided to this research, which includes National Institutes of Health (NIH) grants R56HL156806 and P50AA030407, and the University of Nebraska Collaboration Initiative grants awarded to PKM, and the University of Nebraska Medical Center Presidential Graduate Fellowship granted to FIG

Changes in the expression of those signaling molecules could be part of the underlying mechanism modulating osteoclastogenesis in response to IGF-I (Figure 2)