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72 Cyanocobalamin (but not hydroxocobalamin) is also contraindicated in renal insufficiency

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Therefore, when dietary folate intake is sufficient, patients show normal concentrations of serum folate, but very low CSF 5-methyl-THF ( 300,000 cases a year where over 95% of them are first occurrence

[15] [16] Standard NHS treatment protocols: Without neurological involvement: Hydroxocobalamin 1mg intramuscularly three times weekly for two weeks, then maintenance injections every 2-3 months (lifelong if pernicious anaemia)