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If any of these changes appear, the solution should not be considered reliable for continued research use, regardless of how much time has technically elapsed since reconstitution

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hm 5 C: impact on RNA structure and metabolic stability 5-hydroxymethylcytidine (hm 5 C) is a modification present in both DNA and RNA, formed via m 5 C oxidation by TET (Ten-Eleven Translocation) proteins