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Using a collagen gel contraction assay, we observed that primary fibroblasts from the lungs of aged GHK-treated mice exhibited enhanced contraction compared to fibroblasts from placebo-treated mice (Figure 4), further supporting the hypothesis that GHK promotes the resolution of collagen scars

Cell Rep 2020 Apr 21;31(3):107531 35

This could be linked to the significant hormonal signaling event that's just occurred

Tortorici, M

An integrated approach that addresses multiple aspects of health can provide comprehensive benefits and improve the quality of life for patients with hormonal imbalances

Altered tropomyosin expression or function could therefore amplify pro-fibrotic mechanotransduction pathways, creating a vicious cycle of increasing stiffness and fibroblast activation