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"Dark circles are very common, however hyperpigmentation under the eyes is more common in Asian skin because dark-skinned people have more melanin (the pigment which gives skin its colour) than light-skinned people

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pylori : Helicobacter pylori HtrA: High temperature requirement A ICG: Indocyanine green LA: Linoleic acid Le b : Lewis b LLA: Linolenic acid LNP: Lipid nanoparticles LPN: Lipid polymer nanocarrier Man: Mannose MP: Microparticles MS: Mesoporous silica MTZ: Metronidazole NE: Nanoemulsions ND: No data NP: Nanoparticles OMZ: Omeprazole OA: Oleic acid OMP: Outer membrane proteins PAP: Papain PDT: Photodynamic therapy PE: Phosphatidylethanolamine PECS: Pectin sulfate PLGA: Polylactic-co-glycolic acid PVA: Polyvinyl alcohol RBC: Ranitidine bismuth citrate ROS: Reactive oxygen species SA: Stearic acid SabA: Sialic acid-binding adhesin SDT: Sonodynamic therapy SEM: Scanning electron microscopy sLe x : Sialyl-Lewis x TEM: Transmission electron microscopy UCCs: Ureido-conjugated chitosan UEA-I: Ulex europaeus Agglutinin I WHO: World Health Organization References Cardos IA, Zaha DC, Sindhu RK, Cavalu S