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For instance, the degree of immune cell infiltration and the activity of cancer-associated fibroblasts (CAFs) demonstrate significant variations among subtypes, which may potentially impact treatment efficacy and patient prognosis ( Therefore, understanding the clinical manifestations and biological characteristics of various subtypes is essential for developing effective treatment strategies

Is there human trial evidence, not just anecdotes and rodents

Most of the patients who desperately seek fair complexion or a new treatment modality for their refractory facial melanosis are typically internet and social media savvy

PubMed Central, doi:10.1371/journal.pone.0121535

Dimethyl fumarate is being tested in a Phase 2 trial in Italy (EUTC: 2022-503016-16-00)

10.1016/j.bbi.2015.04.004 109 DickersonF.AdamosM.KatsafanasE.KhushalaniS.OrigoniA.SavageC.et al