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By age 50, you are producing about 30% less collagen than you did at 20, and the collagen you do produce is of lower quality

J Struct Biol (2002) 137(1-2):210

EMT is a biological process wherein epithelial cells acquire mesenchymal properties, losing polarity and adhesion while gaining motility and invasive capabilities [74]

observed reduced ULK1 kinase activity as well as a significantly reduced autophagic flux in response to amino acid deprivation [7]

A little experimentation, combined with guidance from your provider, can go a long way toward finding what clicks for you