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58 VieiraI.SonnierM.CresteilT

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Author contributions EF: Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing original draft, Writing review & editing

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Figure 1 Mel was used as a second drug in only one case, whereupon the subject fell asleep

The studies began with the determination of the optimal dosing for Cagrilintide in both chow-fed and high-fat diet (HFD)-fed wild-type (WT) mice, followed by analyses of its receptor dependence using receptor activity-modifying protein (RAMP) knockout (KO) models, and mechanistic studies involving neuronal activation and gene expression profiling [2]