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Given that recombinant hBNIP3 exhibited a comparable secondary structure composition to recombinant hBAX as determined by CD spectroscopy (Supplementary Fig

4.1.1 Local delivery of RNA-LNPs A straightforward way to bypass hepatic accumulation of LNPs is to change the administration route from intravenous delivery to other administration routes, which could shorten the delivery path and enhance accessibility to the target cells (Figure 3) (Chenthamara et al., 2019

These mechanistic findings, together with the excellent safety profile after methanol and ethylene glycol poisoning and after an APAP overdose, suggest that fomepizole may be a promising antidote against APAP overdose that could be useful as adjunct treatment to NAC

Kidney function, hydration, medications, cystatin C and the overall clinical picture may be important when interpreting follow-up results