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This oversight is consequential: serine and glycine supply one-carbon units for nucleotide biosynthesis in proliferating fibroblasts [1], glutamine fuels macrophage activation and fibroblast collagen secretion [10, 11], arginine is the substrate for nitric-oxide-mediated vasodilation [12], and cysteine underpins glutathione synthesis, buffering the oxidative burst characteristic of the inflammatory phase of wound healing [13]

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For intracellular staining, cells were permeabilized with 4% PFA and 0.01% TritonX for an extra 15 min

doi: 10.21617/jprm.2017.0102.1 73 MawozaT.NhachiC.MagwaliT

(2020) confirmed the effectiveness of molidustat in tumor supression in cultured MDA-MB-231 breast cancer cells and MDA-MB-231 xenograft in vivo