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This dosing strategy allowed evaluation of both the toxic effects of HgCl and the potential dose-dependent protective effects of hesperidin

Repeated measures ANOVA indicated a significant treatment effect, F 3,24 =62.58

Inhibition of the growth of Caco-2 and MOLT 4 cancerous cell lines was observed in a dosage and time-reliant manner, respectively, with considerably high inhibition at 10,000 g/mL and at 120 min, respectively

A., Rubinow, D

Similarly, no significant changes in LINE-1 and Alu methylation among female nurses was observed, although several gene-specific hypomethylation effects to the estrogen receptor gene ESR1 (associated with heightened estrogen sensitivity), to the tumor suppressor genes TP53 and BRCA1 (indicating possible disruption in cell cycle regulation and DNA repair mechanisms) were reported