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Increased levels of HNE have been demonstrated in the MRL/lpr as well as in SLE and associated with increased onset of disease [86, 87]

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Then, two key effectors regulating mRNA translation, p70S6 kinase 1 (S6K1) and eIF4E binding protein (4EBP), will be phosphorylated, thereby promoting protein synthesis (131)

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Exercise may further add to this benefit