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In preclinical heart failure models, NNMT enzyme inhibition markedly reduced cardiac 1-MNA (by 77.1%), improved cardiac function, reduced left ventricular hypertrophy and fibrosis, and decreased pro-inflammatory gene expression

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5-Amino-1MQ 5-Amino-1MQ is a small molecule that inhibits the enzyme Nicotinamide N-methyltransferase (NNMT), which prevents the enzyme NAMPT from converting NAM into NMN, a critical precursor to NAD+

BPC-157 can be administered orally with maintained effectiveness for gut-related applications

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