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The doctor may recommend that women undergo a pelvic examination, and men undergo a prostate examination

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J Obstet Gynaecol Can 39:12211229 Geroin C, Di Vico IA, Squintani G, Segatti A, Bovi T, Tinazzi M (2020) Effects of safinamide on pain in Parkinsons disease with motor fluctuations: an exploratory study

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Given the short half-life, twice-daily dosing provides additional exposure compared to once-daily protocols at the same total dose

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