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Neutralizing antibodies against either domain of AMG 966 competed with biotinylated TNF and/or TL1A for binding to Ru-AMG 966, resulting in a reduced electrochemiluminescent (ECL) signal

doi: 10.1371/journal.pgen.1010400

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To be specific, deletion of GPX4 in T cells resulted in loss of Tfh cells and GC responses in immunized mice, suggesting that Tfh cells are particularly susceptible to ferroptosis