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Interestingly, the relatively higher abundance of polysaccharide-degrading taxa such as Prevotella in the duodenum compared to the jejunum and ileum may reflect passive transfer from the rumen rather than indigenous colonization, highlighting the role of the small intestine as a transitional zone in the digestive continuum 73

Elevated MMA levels indicate a deficiency in adenosylcobalamin (again, it acts as a cofactor for the conversion of methylmalonyl-coenzyme A to succinylcholine coenzyme A), so this indicates that the methylcobalamin was successfully converted to adenosylcobalamin for use in the MMA pathway

Nur E, Biemond BJ, Otten HM, et al

Cano A, Ettcheto M, Chang J-H, Barroso E, Espina M, Khne BA, Barenys M, Auladell C, Folch J, Souto EB (2019) Dual-drug loaded nanoparticles of Epigallocatechin-3-gallate (EGCG)/Ascorbic acid enhance therapeutic efficacy of EGCG in a APPswe/PS1dE9 Alzheimers disease mice model

FBS fetal bovine serum

The intersection of the pharmaceutical-target disease genes was obtained using by jvenn