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Choline is also a key precursor in the production of acetylcholine, the neurotransmitter which regulates the forming of memories, recall of information, the ability to focus, verbal reasoning, and some math skills

In this regard, 18 F-FDG, 18 F- or 11 C-labeled acetate, and 18 F- or 11 C-labeled choline represent the three most studied positron emission tomography (PET) radiotracers in the PCa field (121, 122)