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this phenomenon is also the mechanism of fibrotic reaction in most organs (3)

This effect was associated with increased expression of IGF-1 and VEGF in the primary ossification zone.103 Altogether, the bone anabolic actions of the GH can be, at least in part, mediated by paracrine IGF-1 signaling, which enhances osteoblast activity.104 In fact, the only administration of recombinant IGF-1 to healthy participants results in an increase in circulating levels of bone remodeling markers

55, B117B123

Research on in ovo supplementation of bioactive substances in domestic pigeons is limited

It is difficult at this stage to establish a causal sequence of events that underlie these observations

doi: 10.1021/acsami.5c12666 99 SarlakN.TaherifarA.SalehiF