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Saudi J Gastroenterol: Off J Saudi Gastroenterol Assoc

The lack of standardized methods to evaluate total antioxidant capacity and the oxidation state and the use of inadequate antioxidants and/or improper concentrations of antioxidants lead to failure of numerous clinical trials directed to prevent or mitigate progression of atherosclerosis (230233)

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Vitamin C or ascorbic acid reacts with singlet oxygen ( 1 O 2 ), peroxyl radical (ROO), hydrogen peroxide (H 2 O 2 ), and hydroxyl radical (OH), to form the dehydroascorbate A) and semidehydroascorbate radical (A) as shown in equation below (Phaniendra et al., 2015)

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