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Introduction Cell death marks the end of cell life under both physiological and pathological conditions

J Immunol (2009) 182:476270.10.4049/jimmunol.0802255 140 ArechigaAFBellBDLeverrierSWeistBMPorterMWuZet alA Fas-associated death domain protein/caspase-8-signaling axis promotes S-phase entry and maintains S6 kinase activity in T cells responding to IL-2

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The global prevalence of PD is expected to double by 2040, highlighting the urgent need for disease-modifying interventions, as its economic burden already exceeds $20 billion annually in the U.S