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In addition, SUMO fusions are cleaved by the natural SUMO protease that recognizes the tertiary structure of SUMO with high specific cleavage

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In infant populations, bottle-fed babies exhibit reduced fecal microbiota diversity and decreased numbers of beneficial bacteria such as Bifidobacterium and Parabacteroides [77]

359 Owing to the difficulty in accessing certain inflamed tissues, our understanding of the abundance, phenotype, and functional status of Tregs across different tissues remains limited, and the impact of distinct inflammatory microenvironments on Tregs also remains unclear