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When elevation persisted on a second measurement, the association with incident solid cancer was strong, while a transient elevation carried no greater risk than a normal value

The mTORC1 pathway and ISR are two major amino acid sensing pathways that integrate nutrient availability to cellular adaptations including protein synthesis, metabolism and cell growth 7,8,15,16

The integrated application of multiomics technologies (e.g., single-cell RNA sequencing, integrated proteomics, single-cell metabolomics, and spatial omics) is critical for systematically dissecting intratumoral metabolic heterogeneity, identifying key metabolic subtypes, and revealing patterns of intercellular metabolic crosstalk to address this issue [400]

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5 CEUs each