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*Correspondence: Yi-Pin Lin, [email protected]

Additionally, specific polymorphisms in clock genes may affect individual vulnerability to circadian disruption, thereby influencing the extent to which NSW impacts BC risk and related molecular pathways 219

The free-living nematode Caenorhabditis elegans has already been established as a model for anthelmintic drug discovery due to its ease of laboratory culture, amenability to HTS for rapid whole-organism phenotypic screening, and the availability of extensive forward and reverse genetic methods 16,17,18