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Also, scarcities have been seen to alter the metabolism of certain drugs and xenobiotics in mice

[6] Profound hepatic failure (although methadone seems to be metabolized normally in cirrhosis)

Schuetz P, Seres D, Lobo DN, Gomes F, Kaegi-Braun N, Stanga Z

Many oncometabolites causing mitochondrial disorders and possibly initiating the cancer process have been identified, and as aforementioned, lactate is one of the most ubiquitous oncometabolites in cancer (Kes et al., 2020