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Trends Pharmacol Sci 32:581590 DeWire SM, Yamashita DS, Rominger DH, Liu G, Cowan CL, Graczyk TM, Chen X-T, Pitis PM, Gotchev D, Yuan C (2013) AG protein-biased ligand at the -opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine

Abbreviations CHI: Congenital hyperinsulinism GDH-HI: Glutamate dehydrogenase hyperinsulinism GDH: Glutamate dehydrogenase GLUD1: Glutamate dehydrogenase 1 GLUT2: Glucose transporter 2 GCK: Glucokinase G6P: Glucose-6-phosphate TCA: Tricarboxylic acid KATP: ATP-sensitive potassium GTP: Guanosine triphosphate NADH: Nicotinamide adenine diphosphate hydride ADP: Adenosine diphosphate ATP: Adenosine triphosphate HI/HA: Hyperinsulinism/hyperammonemia HHF6: Familial hyperinsulinemic hypoglycemia-6 -KG: Alpha-ketoglutaric acid DES: Diethylstilbestrol EGCG: Epigallocatechin gallate SIRT4: Silent information regulator 4, Sirtuin 4 MCD: Malonyl coenzyme A decarboxylase NAG: N-acetylglutamate CPS: Carbamoyl phosphate synthetase BCH: 2-Aminobicyclo [2, 2, 1] heptane-2-carboxylic acid GABA: -Aminobutyric acid References Yorifuji T

Moreover, paclitaxel has also been reported to induce neurotoxicity, primarily by affecting neural stem cells and progenitor cells in the hippocampus, which leads to impaired spatial memory (Huehnchen et al., 2017)

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FEMS Microbiol Rev (2010) 34(4):42644

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