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In general, dogs with double coats have sensitive skin, making them more susceptible to irritation, inflammation, and sunburn

Discussion: These findings increase our understanding of PRKAG2 -associated cardiomyopathy, and propose metformin as a novel modality for managing the metabolic and electrophysiological aberrations of this genetic disorder

While dietary restriction has shown promise in attenuating aging biomarkers and extending healthspan by modulating these pathways, its clinical application faces two critical challenges

First, built into the oligomers they may induce an antibody response cleaning away the oligomers

Toxicol Lett 219:178193