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Asian populations exhibit unique genetic risk profiles for diabetes, including a higher prevalence of certain GST polymorphisms and a greater susceptibility to type 2 diabetes at lower BMI levels compared to Europeans

Taken together, these in vitro and in vivo data, confirm an essential role for the IGF-I/IGF-IR signaling in promoting both early- and late-stage osteoclastogenesis (Figure 2)

Glucocorticoids induce differentiation of a specifically activated, anti-inflammatory subtype of human monocytes

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Long-term evidence also indicates most users maintain the weight loss, with less than 5% regaining after three years

All patients provided written informed consent