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However, they often show direct RS scavenging or other biological activity (e.g., inhibition of topoisomerase II)

Additionally, in the DHE staining results, we observed that FOXO4-DRI treatment effectively reduced the ROS levels in the aorta of aged mice (Figure 2F)

Key Clinical Distinction Vitamin B12 treats a specific deficiency with defined risks if left untreated

VIC also stimulates iron absorption at the intestinal level by reducing Fe 3+ to Fe 2+ , making it more stable and contributing to anemia management [2,8,10]

BRs have been shown to be effective even in micromolar concentrations

National Institutes of Health Accessed October 29, 2025