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Cleveland Clinics health articles are based on evidence-backed information and review by medical professionals to ensure accuracy, reliability and up-to-date clinical standards

[DOI] [PubMed] [Google Scholar] 93.Arakawa T, Ejima D, Tsumoto K, Obeyama N, Tanaka Y, Kita Y, Timasheff SN

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HGF/c-Met signaling pathway with its downstream effector components (MAPK, STAT, PI3K-AKT cascades and NF-B) increase cell survival, motility and proliferation [51]

The strong reduction of Iba1 is particularly noteworthy because human and animal studies have shown that microglia can be chronically activated for weeks to years after brain trauma (Gentleman et al, 2004

Similarly, in primary neurons, we also found that knockdown of A-SYN by siRNA lentivirus mitigated hypoxia-induced neuronal death (Supplemental Fig