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The BBB, as the ultimate defense barrier of the CNS, serves as the synergistic hub of the immune-metabolism-microbiota network: overactivation of immune cells (e.g., microglia), oxidative damage associated with ferroptosis, and microbiota dysbiosis-induced BBB permeability increases collectively constitute the triple hit of C

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Because previous studies have suggested that sex hormones such as estrogen have shown to have neuroprotective properties in animal models with focal and global cerebral ischemia, Caceres et al

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