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Moreover, supplements may react when taken in higher doses without gradual introduction

JR wrote the manuscript with input from KK, BM and TPD

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naturally small molecular reducing agents will never be as specific as the substrate-specific enzymes of the well-controlled antioxidant machinery of the cell, however with a finely tuned and designed thiolate basicity the redox potential and therefore the selectivity of the antioxidant thiol can be confined to a narrower range

The acetyl moiety prevents the thiol group from oxidizing before absorption, shields the molecule from -GT-mediated hydrolysis in the intestinal lumen, and increases lipophilicity facilitating passive diffusion across intestinal epithelium and cell membranes

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