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In addition to glucose metabolism in cancer cells, amino acid metabolism has also become a research hotspot, notably treatments related to the restriction of amino acid metabolism that can selectively target highly proliferative cancer cells (Fig

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Although peripheral and central enterostatin administration decreases dietary fat intake in animals (while enterostatin-receptor antagonists did the opposite) (186), its administration to humans has shown no effects on food intake, appetite, energy expenditure, or body weight (187)

It does so by disrupting the activities and transportation of the melanin-producing enzyme, tyrosinase

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