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Cys 2 ) and cystine-free (Cys 2 -free) medium with vehicle (DMSO) or RSL3 (250 nM), alone or with Fer-1 (10 M) or Trolox (100 M)

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2.3 Physicochemical and ADMET studies The methods used to determine the physicochemical and absorption, distribution, metabolism, elimination, and toxicity (ADMET) properties of RG7774 can be found in Supplementary Methods S2

Ultimately, it seems as though injury to the NMJ is a culmination of mutant protein aggregation at the presynaptic nerve terminal, presynaptic cholinergic dysfunction, impaired axonal transport, reduced synaptic acetylcholinesterase, and diseased muscle itself, among others [292]

Molecules 23:965

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