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** Dichloroacetate effects on glucose and lactate oxidation by neurons and astroglia in vitro and on glucose utilization by brain in vivo

However, the NAC monotherapy arm (600 mg three times daily) showed a trend toward slower decline in forced vital capacity (FVC) that did not reach statistical significance compared to placebo (Martinez et al., N Engl J Med, 2014) [45]

Solvent evaporation method was used for the nanoparticle preparation, producing uniform particles averaging 24 m in size

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Funding CWI is supported by the Interdisciplinary Center for Clinical Research (IZKF) at the University of Wrzburg (A-303 to CWI, A-421 to CWI and JWi, N-362 to CWI), by the Deutsche Stiftung Neurologie and the ParkinsonFonds Germany and by the University Research Funds of the State of Bavaria