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The accumulation of succinate supported by -KG controlled decarboxylation has been described to inhibit PHD, and thereby, HIF hydroxylation, leading to HIF stabilization and activation in normoxia [21, 43]

These structural data suggest the tetrameric form of SnCE1 might be impaired regarding the deSUMOylase activity

PMID 22479358

The committees recommendation is advisory, and the FDA will now review the recommendation, public comments and the administrative record before determining whether to move forward with rulemaking

Two patients were diagnosed with plasma cell myeloma within 2 months after starting B 12 therapy

Sepsis and cerebral dysfunction: BBB damage, neuroinflammation, oxidative stress, apoptosis and autophagy as key mediators and the potential therapeutic approaches