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Increased FAO in cytochromes may then be an important event in steatosis and NASH, with the excessive amount of ROS produced by the CYP enzymes exacerbating hepatic oxidative stress and consequently worsening liver damage

For example, severe systemic G6PD deficiency predisposes to bacterial and fungal infections, while Pgd knockout in T cells putatively promotes antitumour immunity 121

For example, Cas9 can successfully introduce DSBs at specific sites to introduce small insertions or deletions (indels) into the genome, and the introduced DSBs cause the formation of gene byproducts that disturb intracellular genome stability

Biomater Sci (2020) 8:55268

Cytotherapy, 8 (4), 315317

The same method was used to measure in vivo brain levels of lactate and N-acetylaspartate (NAA) as markers of mitochondrial dysfunction