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Such interactions create crosstalk between epigenetic layers: MeCP2, a methyl-DNA binding protein, can recruit histone modifiers, while histone acetylation status influences DNA methyltransferase access to chromatin 181,182

In addition to the acute irritant toxicity, these TCMs possess maternal and developmental toxicity, which can cause embryo resorption, growth retardation, structural malformations, and even abortion

Aizenman E, Sinor JD, Brimecombe JC, Herin GA

When taken in a higher dosage, the pathway of melanin is altered, and it is proven to reverse the melanins metabolism

doi: 10.3389/fmicb.2020.01383 Received 15 February 2020 Accepted 28 May 2020 Published 25 June 2020 Volume 11 - 2020 Edited by Frank Ebel, Ludwig Maximilian University of Munich, Germany Reviewed by Hubertus Haas, Medical University Innsbruck, Austria