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This testing is added based on the criteria described above in When to test. In people without Down syndrome, studies have demonstrated that red blood cell folate and serum folate testing provide equivalent data

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Int Immunopharmacol 31:98104

We have shown previously that sirtuins SIRT1 and SIRT3 have anti-fibrotic function, and their decreased tissue expression observed in skin biopsies from SSc patients, might directly contribute to the persistence of fibrosis 28,29