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[,] Owing to acute liver failure, chronic hepatitis, or cirrhosis, the clearance of ammonia by the liver is diminished, they may reach to the brain, the elevated levels of ammonia and an inflammatory response work in synergy to cause astrocytes to swell and fluid to accumulate in the brain (cerebral edema), thus, affect cerebral function [,] [Figure 7]

The metabolic reprogramming of NADPH renders cancer cells both highly dependent on this metabolic network for antioxidant capacity and more susceptible to oxidative stress

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Xie MZ, Li JL, Cai ZM, Li KZ, Hu BL