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As a constituent element of enzymes and proteins, copper regulates diverse biochemical processes, including energy production, the regulation of transcription factors, and the induction of reactive oxygen species (ROS) [3, 4]

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On day 21, tumor progression was evaluated using bioluminescence imaging with the IVIS system (Caliper Life Sciences) following intraperitoneal injection of D-Luciferin potassium salt (3 mg/kg per mouse, administered 5 minutes prior to imaging, Beyotime, ST198) and anesthesia with 1% pentobarbital sodium (80 mg/kg per mouse)

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