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K.LundholmC.HalfvarsonJ.LudvigssonJ

10.1016/j.neures.2022.08.006 42 GengD.WuH

Another strategy is utilizing PARP inhibitors, which resulted in rescuing NAD + levels and decreasing A aggregation in brain samples of AD flies, however, this study did not include any measurements of mitochondrial function 275

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MTHFR converts 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, the cofactor form necessary for the re-methylation of homocysteine to methionine (see Figure 2 above)

Given that age and sex ratio were unevenly distributed between the ASD and HC groups and the HC subjects were from different sources (local community, kindergarten/primary school and clinical center) in some included studies (eTable 1), we performed the stratified analyses based on the three factors