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Although the pathophysiology of CP is not well understood, several hypotheses have been studied (68)

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Food Sci Technol Bull

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Punicalagin induces Nrf2/HO-1 expression via upregulation of PI3K/AKT pathway and inhibits LPS-induced oxidative stress in RAW264.7 macrophages

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Moreover, the severity of the clinical phenotype is patient-dependent

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Osthole inhibits bone metastasis of breast cancer

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doi: 10.1177/8755122518780742 97

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