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In vivo studies in mice and rats showed that mitochondrial defects persisted beyond the acute phase of infection, correlating with high mitochondrial ROS (mtROS) levels during chronic disease phase (Wen et al., 2008, 2017

457 Two independent phase 2 clinical studies (NCT03464500, NCT03283462) of urolithin A supplementation revealed that 4 months of urolithin administration enhanced muscle endurance and offset age-related muscle decline

Even between disease flares, low-level inflammation irritates and damages intestinal tissue, which can lead to malignancy

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But the biology behind GHK-Cu anti-inflammatory signaling, antioxidant activity, and support for collagen and skin-barrier repair does overlap with what dermatologists target when managing flare-prone, reactive skin

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