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More is not always better, and thoughtful protocol design often outperforms brute force approaches over time

A common educational reference method uses 3.0 mL of bacteriostatic water, resulting in a final concentration of 16.67 mg/mL

In the primary analysis using the trial product estimand, which evaluated participants who adhered to treatment, bodyweight decreased progressively in all active treatment groups over the 26-week period, without clear evidence of reaching a plateau

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doi: 10.1016/j.tjpad.2025.100214 235 SelkoeD