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By extracting aortic tissue from the mice and performing WB analysis, we found that the expression levels of P53 and FOXO4 were both elevated (Supplementary Figure S1A)

CagriSema submitted for FDA approval in December 2025 with expected approval in Q4 2026 or Q1 2027, meaning launch around mid-2027

For retatrutide , phase 2 data published in the New England Journal of Medicine (2023) demonstrated substantial mean weight reductions over 48 weeks in adults with obesity among the highest figures reported for any pharmacological agent to date

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Immunohistochemical staining showed higher expression of p16 in keloids than that in normal skin ( p = 0.01

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