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Because secretagogues amplify natural GH pulses rather than creating a pharmacokinetic peak from outside, dosing in the evening (near sleep onset) aligns the induced pulse with the body's largest natural nocturnal GH surge

Unfortunately, as sermorelins FDA approval was withdrawn in 2008 (for reasons other than safety and efficacy), there is very limited clinical trial data to indicate what long-term effects this peptide may produce

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At the same time, the activity of antioxidant enzymes (SOD, GPX, GR) in cardiomyocytes is weaker than that in other organs [17], further aggravating the susceptibility to this injury

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