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From there, it may interact with multiple signaling cascades involved in cellular communication and regulation

This angiogenic effect appears to work through the upregulation of vascular endothelial growth factor (VEGF) and other growth factors critical for tissue repair

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Conversely, hypoxia and glucose deprivation in the brain promotes HDAC9 expression in endothelial cells, which has been associated to decreased expression of ZO-1, claudin-5, and occludin (Shi et al., 2016)

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Nahurira R, Ren L, Song J, Jia Y, Wang J, Fan S, Wang H, Yan Y (2017) Degradation of di(2-ethylhexyl) phthalate by a novel Gordonia alkanivorans strain YC-RL2