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As prominent phospholipids in cell membranes, PUFAs are particularly susceptible to peroxidation, resulting in disruption of membrane integrity and permeability in cancer cells, ultimately favoring induction of ferroptosis (Endale et al., 2023)

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Therefore, inhibition of GSDME cleavage or/and its pore formation activity can potently inhibit liposome leakage and pyroptosis

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The consumption of iodized salt, which contains 1050 mg of iodine per kg of salt, is recommended in cases of iodine deficiency